is a Knowledge Graph.
It is part of the OKN collection.
Scalable Precision Medicine Open Knowledge Engine (SPOKE) is a comprehensive biomedical knowledge graph that connects diverse data from multiple domains to enable discovery and precision medicine applications.
biomedical, genomics, clinical, drug discovery, precision medicine, pharmacology
infores:spoke
Unknown
| ID | Name | URL | Category | Format | Description |
|---|---|---|---|---|---|
| spoke.graph | SPOKE Graph | data-tools | GraphProduct | http | The SPOKE knowledge graph containing ... |
| spoke.neighborhood_explorer | SPOKE Neighborhood Explorer | neighborhood.html | GraphicalInterface | http | Web interface that allows searching S... |
| spoke.sparql | SPOKE SPARQL Endpoint | sparql | ProgrammingInterface | http | SPARQL endpoint for querying SPOKE kn... |
| spoke.docs | SPOKE Data and Tools | data-tools | DocumentationProduct | http | SPOKE data and tools page describing ... |
SPOKE (Scalable Precision Medicine Open Knowledge Engine) is a comprehensive biomedical knowledge graph developed at the University of California, San Francisco (UCSF). It integrates data from over 30 public databases to create a rich network of biomedical relationships.
SPOKE is a heterogeneous network, containing different types of nodes (e.g., genes, diseases, drugs, pathways) and the edges between them represent known connections. The knowledge graph pulls data out of silos, connecting diverse information from molecular research, clinical insights, and environmental data.
SPOKE enables a wide variety of applications including suggesting testable hypotheses for researchers, implicating mechanisms of disease, and enabling more precise diagnoses and treatments for individual patients. It has been used in studies for drug repurposing, disease prediction, and integrating electronic health records with biomedical knowledge. In KG-Registry, the owned products capture the main SPOKE access points, while the detailed original-source provenance on the graph product records the many upstream resources incorporated into the network.
Created: March 09, 2025 | Last modified: May 30, 2026